Experimental evolution of Staphylococcus aureus in macrophages: dissection of a conditional adaptive trait promoting intracellular survival
ABSTRACT Staphylococcus aureus is a major pathogen associated with important diseases in humans and animals.Macrophages are a key component of the innate immune response to S.aureus infection and play a major role in disease outcomes.To investigate the adaptive evolution of S.aureus in response to macrophages, we developed an experimental infection